Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
نویسندگان
چکیده
The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.
منابع مشابه
Efficacy and pharmacodynamics of linezolid, alone and in combination with rifampicin, in an experimental model of methicillin-resistant Staphylococcus aureus endocarditis.
OBJECTIVES To evaluate the efficacy of oral linezolid, with or without rifampicin, on valve vegetations and secondary foci of infection compared with vancomycin, in the absence or presence of rifampicin, in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus. METHODS Treatment groups were controls (n = 16), linezolid (n = 15), vancomycin (n = 15), linezolid and rif...
متن کاملIn vitro activity of linezolid alone and in combination with glycopeptides against methicillin-resistant Staphylococcus aureus
The emerging resistance to antibiotics and the poor pipeline of new antibacterials is creating a major health issue worldwide. Combinations of two antibiotics or antibiotics with adjuvant are emerging as a promising therapeutic approach. Staphylococcus aureus represents a major threat to a broad range of healthcare and community associated infections. It is imperative to develop novel antimicro...
متن کاملEfficacy of linezolid in treatment of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
The efficacies of orally (p.o.) dosed linezolid and intravenously (i.v.) dosed vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) in rabbits with experimental aortic-valve endocarditis were investigated. After endocarditis was established with a recent clinical MRSA isolate, rabbits were dosed for 5 days with linezolid (p.o., three times a day) at either 25, 50, or 75 mg/kg o...
متن کاملCeftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus.
Beta lactam agents are the most active drugs for the treatment of streptococci and methicillin-susceptible Staphylococcus aureus endocarditis. However, methicillin-resistant S. aureus (MRSA) is resistant to all beta lactam agents licensed to date, and alternative treatments are limited. Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the penicillin ...
متن کاملSingle- and combination-antibiotic therapy for experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
The efficacy of fosfomycin in combination with vancomycin or gentamicin was evaluated in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus. After 5 days of therapy, both combinations proved to be highly effective since all rabbits had sterile vegetations.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 47 9 شماره
صفحات -
تاریخ انتشار 2003